赵丽茹博士
语言
RESEARCH PROGRAMS AND AFFILIATIONS
研究兴趣
Brain plasticity; molecular, cellular 和 functional mechanisms of brain repair in traumatic brain injury, 中风, 阿尔茨海默病, 和CADASIL. Pathological mechanisms underlying the development 和 progression of brain injury, neurodegenerative 和 genetic diseases.
ASSOCIATIONS / MEMBERSHIPS
研究抽象
研究抽象
The long-term goal of our research is to develop new therapeutic strategies for 中风, 阿尔茨海默病, CADASIL疾病, 以及创伤性脑损伤.
Our current research focuses on enhancing brain repair after brain damage by either brain disease or injury. The major approaches used for our study include molecular biology, 细胞生物学, 显微外科, 实时脑成像, 流式细胞术, motor function 和 cognitive function assessment, immunohistochemistry 和 brain section imaging.
中风 is considered a brain attack 和 is ranked as the number one cause of long-term disability in adults. 阿尔茨海默病 (AD) is a neurodegenerative disease that causes irreversible progressive brain damage 和 memory loss. Cerebral autosomal dominant arteriopathy with subcortical infarcts 和 leukoencephalopathy (CADASIL) is a rare hereditary 中风 disorder 和 an autosomal dominant vascular dementia. 目前, there is no drug that can improve the functional outcome for 中风 nor is there a treatment that can stop or delay the progressive brain damage caused by AD or CADASIL.
We have recently demonstrated the therapeutic effects of bone marrow stem cell factors on brain repair in animal models of 中风, 阿尔茨海默病 和CADASIL疾病. Our laboratory is studying how the bone marrow stem cell factors repair the brain in these devastating diseases. In addition to the in vivo study, we are also determining how the bone marrow stem cell factors regulate neuronal process formation, 突触的一代, 干细胞生长, motility 和 differentiation. We are also gaining an underst和ing of the detailed process of how stem cells promote neuronal network development.
选定的出版物
1. 赵L.-R.、段伟.-M.雷耶斯·M.基恩·C.D.; Verfaille.M. 低W.C. Human bone marrow stem cells exhibit neural phenotypes 和 ameliorate neurological deficits after grafting to ischemic brain in rats. 实验神经学, 2002; 174: 11-20.
2. 赵LR, Singhal S、段伟M, Mehta J,凯斯勒 JA. Brain repair by hematopoietic growth factors in a rat model of 中风. 中风, 2007; 38:2584-2591.
3. 赵LR, Berra HH、段伟M, Singhal 年代,梅塔 J, Apkarian AV, Kessler JA. Beneficial effects of hematopoietic growth factor therapy in chronic ischemic 中风 in rats. 中风, 2007; 38:2804-2811.
4. 赵LR, Navalitloha Y, Singhal 年代,梅塔 J,凯斯勒 是的,朴 CS,郭 WP, Groothuis DR. Hematopoietic growth factors pass through the brain-blood barrier in intact rats. 实验神经学, 2007; 204:569-573.
5. C-S Piao, M E Gonzalez-Toledo, Y-Q Xue, W-M Duan, S Terao, D N Granger, R E Kelley 和 唐森赵. The role of stem cell factor 和 granulocyte-colony stimulation factor in brain repair during chronic 中风. JCBFM. 2009; 29:759-770.
6. Bin Li, Maria E Gonzalez-Toledo, Chun-Shu Piao, Allen Gu, Roger E Kelley, Li-Ru Zhao. Stem cell factor 和 granulocyte-colony stimulating factor reduce β-amyloid deposits in the brains of APP/PS1 transgenic mice. 阿尔茨海默氏症的研究 & 治疗. 2011; 3:8.
7. Piao CS, Li Bin, Lijuang Zhang, 赵LR*. Stem Cell Factor 和 Granulocyte-Colony Stimulating Factor Promotes Neurogenesis 和 Inhibits Glial 分化. 分化, 2012;83:17-25.
8. 崔丽丽，Sasidhar R. Murikinati, D Wang, Xiangjian Zhang, Wei-Ming Duan, Li-Ru Zhao. Reestablishing neuronal networks in the aged brain by stem cell factor 和 granulocyte-colony stimulating factor in a mouse model of chronic 中风. 《推荐最近最火的赌博软件》. 2013;8:e64684.