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Guillain-Barré Syndrome

Definition

Guillain-Barré syndrome is a rare problem that causes the immune system to attack the nerves. This results in muscle weakness. It can range from mild to 严重的. Most people will get better.

Nervous System
CNS 和 PNS
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原因

的 exact cause is not known. In some people, it is triggered by a recent infection.

Risk Factors

Guillain-Barré syndrome is more common in men. 的 risk gets higher with age. Other things that may raise the risk are:

  • Recent infection
  • Stress related disorder
  • Recent vaccination (rare)

症状

Problems may happen over hours, days, or weeks. 的y get worse 随着时间的推移. Problems may be:

  • Weakness 和 tingling in the legs, arms, 和 face
  • Pain in the legs or back
  • Problems walking or climbing stairs
  • Problems breathing
  • Eyesight problems
  • Problems swallowing, speaking, or chewing
  • Problems passing urine (pee)

诊断

的 doctor will ask about symptoms 和 past health. A physical exam will be done. This is often enough to diagnose Guillain-Barre syndrome. 的se 测试 may be done to support it:

Treatment

的 goal is to manage symptoms 和 help speed healing. Hospital care will be needed to watch for things like breathing 和 heart problems. Most people get better, but others may have lasting problems.

Treatment options are:

IV Immunoglobulin 治疗 (丙种球蛋白)

Immunoglobulins are proteins in the blood that fight infections. 丙种球蛋白 uses an IV to give a person proteins donated from a healthy person.

Plasmapheresis

Plasmapheresis 删除 blood from the body 和 passes it through a machine that separates blood cells. 的 cells are then returned to the body with new plasma. This may help a person get better faster.

治疗

Physical 和 occupational therapy may be needed. It can help a person with strength 和 motion. It can also help a person learn how to do daily tasks again.

Prevention

的re are no current guidelines to prevent this problem. 然而, flu vaccines may not be advised for:

  • People who had Guillain-Barre syndrome within 6 months of a flu vaccine, AND
  • Who are not at high risk for 严重的 problems from the flu

This may help reduce their risk.

References

  • Donofrio PD. Guillain-Barré Syndrome. Continuum (Minneap 明尼苏达州). 2017 Oct;23(5, Peripheral Nerve 和 Motor Neuron Disorders):1295-1309.
  • Guillain-Barre syndrome. Centers for Disease Control 和 Prevention website. 可用 at: http://www.疾病预防控制中心.gov/campylobacter/guillain-barre.html.
  • Guillain-Barre syndrome. EBSCO DynaMed website. 可用 at: http://www.力学.com/condition/guillain-barre-syndrome.
  • Guillain-Barre syndrome. National Institute of Neurologica Disorders 和 中风 website. 可用 at: http://www.研究所.国家卫生研究院.gov/health-information/disorders/guillain-barre-syndrome.